The Egyptian Orthopaedic Journal

: 2016  |  Volume : 51  |  Issue : 2  |  Page : 101--110

Single-stage versus two-stage revision of total hip replacement for contained periprosthetic infection

Ayman M Ebied 
 Department of Orthopedic and Trauma Surgery, Menoufia University Hospital, Menoufia, Egypt

Correspondence Address:
Ayman M Ebied
Number 3, El Zahraa Tower, Gamal Abdul Naser Street, Sharaf Square, Shebin El Kom


Objective In this article, single-stage exchange arthroplasty for periprosthetic hip infection was compared with the two-stage revision protocol in patients without draining sinuses. Background Staged revision for periprosthetic infection of the hip is an accepted and widely used technique by many surgeons. However, single-stage exchange of the hip prosthesis remains an attractive option to some. Patients and methods Fifty-two patients with evidence of periprosthetic infection underwent preoperative aspiration of the affected hip. The organism was identified in 33/52 patients, and single-stage revision was performed. The remaining 19 patients underwent two-stage exchange arthroplasty. All patients had cemented cup and long cementless stem. Results At an average 4 years (range: 2–7 years) postoperatively, only one case of persistent infection was found in the single-stage group, which showed a success rate of 97%, in comparison with 95% success rate in the staged protocol. Conclusion Single-stage exchange achieves excellent success rates in patients with contained infection when the organism is identified preoperatively.

How to cite this article:
Ebied AM. Single-stage versus two-stage revision of total hip replacement for contained periprosthetic infection.Egypt Orthop J 2016;51:101-110

How to cite this URL:
Ebied AM. Single-stage versus two-stage revision of total hip replacement for contained periprosthetic infection. Egypt Orthop J [serial online] 2016 [cited 2018 Apr 26 ];51:101-110
Available from:

Full Text


Staged revision for periprosthetic infection of the hip is an accepted and widely used technique by many surgeons [1],[2]. However, single-stage (SS) exchange of the hip prosthesis remains an attractive option to some because of the advantages of reduced risk for comorbidities, shorter treatment time and hospital stay, in addition to reduction in the cost of treatment [3],[4],[5],[6].

There are many contradictory reports on the results of SS exchange hip arthroplasty, with high success rates in some and unfavorable results in others [7],[8],[9]. This contradiction may be related to the differences in the method of patient selection, technique of implant exchange between cemented and noncemented hips, and the postoperative antibiotic (AB) protocol [9].

The advantages of the staged revision strategy are better identification of the infecting organisms and doubling the chance of performing a thorough debridement of the infected tissues [10],[11],[12]. This, however, does not rule out the benefit of performing SS exchange in some patients [13]. The question remains: how can one define the category of patients who would benefit the most from each technique?

Manifestations of infection vary from late loosening of implants that might have lasted for many years to be discovered at the time of elective revision to an acute periprosthetic infection with draining sinuses and septicemia [14]. These manifestations are related to the patient’s general condition, the infecting organism, local soft tissue condition, and bone defects [15].

It has been hypothesized that patients who present with active draining sinuses, general symptoms of acute infection, in addition to poor local soft tissue condition and previous multiple surgical procedures are those with an uncontained infection process. On the other hand, patients with periprosthetic infection of the hip who do not have the above findings are considered as patients with contained infection.

This research aimed at investigating whether patients with contained periprosthetic infection as defined above are good candidates for SS exchange arthroplasty.

 Patients and methods

Fifty-two patients with contained periprosthetic infection of the hip according to the previous definition were included in this prospective study that was conducted between August 2006 and September 2012. Approval of the local research committee was obtained, as well as patients’ consent for inclusion into the study.

Patients were subjected to preoperative aspiration of the hip in a sterile theater under radiographic control, and specimens collected were directly cultured on blood agar for 2 weeks.

On the basis of the culture results, the patients were divided into two groups. Patients with an organism identified in the culture were enrolled for SS exchange arthroplasty. The other group that showed negative culture results with no growth or for whom aspiration was not successful were scheduled for the two-stage (TS) revision protocol.

Preoperative assessment of patients’ general condition was performed, bone defects on the femoral and acetabular sides were graded according to American Academy of Orthopaedic Surgeons classification, and Harris Hip Score (HHS) for hip function was recorded.

The single-stage revision

All patients were operated upon in the lateral decubitus position using the posterior approach described by Gibson–Kocher and extended trochanteric osteotomy as previously described [16].

The length of the osteotomy from the tip of the greater trochanter was determined according to the need to remove distally fixed cement mantles. In all cases, the exposure allowed removal of distal cement mantles and infected membranes.

In addition to removal of the implants and bone cement, extensive debridement of all infected tissues and membranes on the femoral and acetabular sides was performed, reaching viable bleeding tissues. On the acetabular side, special attention was given to removing the hip capsule, whereas on the femoral side meticulous debridement of the medullary canal, calcar area, and inner surface of the greater trochanter was regularly performed. A minimum of six tissue specimens were collected and sent for standard and extended (2 weeks) culture and AB sensitivity tests.

Once the debridement had been completed, intravenous infusion of AB was commenced. Patients’ drapes, surgeons’ gowns, and surgical instruments were replaced by newly sterile equipment.

Assessment of acetabular bony defects was performed and impaction graft for acetabular defects was performed using a fresh frozen femoral head allograft. The graft was prepared by removing all attached soft tissues and cartilage and then dividing the remaining cancellous bone using a power saw and manual rongeurs into bone chips 8–12 mm in size. ABs in powder form ([Figure 1]) were mixed with the cancellous chips of each femoral head allograft [17],[18],[19]. The bone chips were then impacted progressively in layers into the acetabular defects until they were fully seated and filled the defects [20],[21] ([Figure 2]a–[Figure 2]c).{Figure 1}{Figure 2}

Acetabular defect grades III and IV were augmented by a Burch-Schnieder cage with superior and posterior screw fixation (Zimmer GmbH, Winterthur, Switzerland).

High cross-linked all polyethylene cups with an inner diameter of 32 mm were cemented in all acetabulae (ZCA, longevity cross-linked all poly cup; Zimmer GmbH) using standard high-fatigue gentamycin-loaded bone cement. The powder of one vial from the mentioned AB was added to each pack of 40 g bone cement after 1 min from the beginning of the mixing process [22],[23],[24].

On the femoral side straight Wagner SL revision cementless stems (Zimmer GmbH) were inserted into all femora, having accepted the height and rotation of the trial prosthesis. A 32 mm outer diameter cobalt chrome heads were selected in all cases.

Reattachment of the osteotomized trochanter was finally performed using stainless steel (Ortron; DePuy Synthes Companies Codman. A division of Johnson & Johnson Medical Ltd., Pinewood Campus, Nine Mile Ride, Wokingham, RG40 3EW, United Kingdom) doubled wires and soft tissue repair of the external rotators using Ethibond No. 5 (Ethicon, J&J, USA) transosseous sutures.

Staged revision protocol

In the staged revision protocol, all the steps mentioned previously till the infusion of AB at the end of the debridement were followed. Then a handmade cement spacer with an internal metal splint was fashioned to fill the acetabulum and be stable within the femoral medullary canal. Reattachment of the greater trochanter was then performed using Ethibond No. 5 ([Figure 3]a–[Figure 3]d).{Figure 3}

Postoperative antibiotic protocol

In the case of SS revision, intravenous infusion of ABs according to the preoperative culture results was commenced intraoperatively and continued until tissue biopsy culture results were available. In all cases, a minimum of 2 weeks of intravenous AB infusion of the suitable AB was given ([Table 1]). After the fourth week, oral AB was continued for another 6–8 weeks according to the sensitivity test of the organism ([Table 1]).{Table 1}

For patients enrolled in the staged protocol, the usual combination of ABs was meropenem, rifampicin, and ciprofloxacin until the culture results were available, when the type and dose of ABs were amended. Patients were continued on the AB for 6 weeks. Then ABs were stopped for 2 weeks before the second stage.

The technique for reimplantation in the staged protocol patients was exactly the same as that performed for the SS patients. Further, AB was given after the second stage for 6–8 weeks as described in the earlier section.

Patients were allowed touch weight bearing (WB) mobilization from the second postoperative day onward for 6 weeks. Partial WB gradually progressed from the 6th to the 12th week, when full WB was permitted.

Laboratory assessment of the patients’ erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) was conducted on a weekly basis during the first 6 weeks, then every 2 weeks for another 6 weeks, and then at 6 and 12 months from surgery. Similarly, radiographs were taken immediately postoperatively and then at 3, 6, and 12 months. The HHS was recorded at the end of 6 and 12 months, and then annually.

Patients who could not attend checkups after the second postoperative year were contacted by phone, and details of any change in their condition were recorded.

The Wilcoxon matched-pairs signed-ranks test was used to compare preoperative with postoperative results and SS patients with TS patients.


Fifty-two patients of an average age of 61 years (range: 41–73 years) were included in this study. All patients had contained periprosthetic infection. Twenty-three patients were female and 29 were male. These patients were divided between two treatment protocols – SS and TS revision – according to the preoperative aspiration results and were followed up for an average of 4 years (range: 2–7 years).

Preoperative aspiration

The aspiration was successful in revealing the organism preoperatively in 33 patients, whereas in 19 patients the culture results were either negative (nine samples) or adequate samples to be processed could not be collected (10 patients).

In cases where the infecting organism was identified by preoperative aspiration, the same organism was confirmed by the tissue specimen cultures that were collected at the time of surgery in all cases. However, additional microbes were detected in three patients ([Table 1]).

Infection control

At the latest follow-up, 32 (97%) out of 33 patients from the SS revision group were free of infection, whereas the TS protocol for revision successfully eradicated infection in 18 (95%) out of 19 patients.

Bone defects and impaction graft

Impaction graft was performed in all patients of the SS revision group and in 11 of the 19 patients of the TS revision group. The magnitude of bone defects is shown in [Figure 4]a and [Figure 4]b. Radiological assessment of graft incorporation was made using the criteria applied in previous reports [25],[26]. No case of graft resorption or lysis was observed in these patients. Incorporation and maturation of the graft within the previous defects was recorded in 31 out of 44 patients who had the impaction graft ([Figure 2]c). It was not possible to observe trabecular arrangement within the graft in cases where a metal cage had been inserted. Using the criteria described by DeLee and Charnley [27] radiolucent lines were seen in zone II in three patients and in zone I in two patients.{Figure 4}

Trochanteric union

Bony union of the extended trochanteric osteotomy was reported in 31/33 patients in the SS and in 14/19 patients in the TS group ([Figure 2]c). Three hips in the TS group had proximal migration of the trochanter by more than 10 mm. None of the patients in the SS group had proximal migration of the trochanter.

Functional results

The HHS significantly improved from the preoperative to the postoperative period ([Figure 5]). There was no difference in the preoperative scores between patients who received SS and those who received the TS protocol. However, significant difference was observed in the postoperative HHS of patients who received SS versus those who received TS, with the SS patients achieving better results (P<0.002).{Figure 5}


One patient in the SS group had a single dislocation that was reduced by closed reduction and continued to be stable afterward. Two patients in the TS revision group had dislocation; in one of them the instability was recurrent and a hip brace was used.

One patient from the SS group had hematoma formation at the wound site that was derided in the theater 1 week postoperatively and the patient had an uneventful recovery.

Two patients in the TS group had intraoperative fractures in the form of extension of the trochanteric osteotomy in one and split along the medial wall of the proximal femur in another. The same type of split was also seen in one patient in the SS group. All fractures were united with the use of circular wires, extending the period of partial WB to 12 weeks.

There were two patients (one patient in each group) who died at 4 and 5 years postoperatively from heart attacks and no patient died during the course of treatment.


One of the challenges faced by orthopedic surgeons is defining the best indication for a SS revision. Distinguishing patients who would most benefit from a SS exchange has implications on the cost of this type of surgery as well as on the patients’ functional outcome and their quality of life.

As correctly stated, infection is the underlying cause of many painful pathologies in joint arthroplasty [14] and therefore should not be overlooked. With this concept in mind, the spectrum of cases that are now considered to have periprosthetic infection, in addition to another indication for revision, is on the rise [13],[14],[28],[29],[30],[31]. It would then be necessary to differentiate between two categories of patients: the first are those presenting with local or systemic manifestations of uncontrolled and virulent infection; the second group consists of those with evidence of infection that has affected the status of their prosthesis without resulting in systemic manifestations or local draining sinus. In this article the first group of patients was defined as having an uncontained infection process. This category of patients would be better off being treated with a staged revision protocol and therefore were not included in this study.

The second group of patients was identified to have periprosthetic infection diagnosed through the history of delayed wound healing, early loosening of their hip implants, radiological evidence of infection, as well as elevated ESR more than 30 and CRP more than 10. However, none of these patients had an active draining sinus or evidence of septicemia. These patients were defined as patients with contained periprosthetic infection.

Successful eradication of infection would only happen through adequate debridement of all infected tissues as well as implants in addition to, and equally important, delivering the correct AB in the appropriate dose [6],[8]. Therefore, defining the infecting organism preoperatively is an essential step in the selection criteria for a SS revision [3].

The value of preoperative aspiration has been emphasized in many studies [32],[33],[34],[35]. This procedure is established in the American Academy of Orthopaedic Surgeons paradigm for diagnosis of infection [36]. The limitation is still on the ability to identify an organism preoperatively in the cases known to be infected. Williams et al. [37] reported the overall accuracy of preoperative hip aspiration in defining the infecting organism as 90.1% with 84% sensitivity and 94% specificity.

In another study of the same group the positive predictive value of hip aspiration in the radiology department was 74%, whereas the negative predictive value was 94% [38].

In this study, preoperative aspiration has been successful in identifying the organism in 33/52 (63%) patients. In 10/52 (19%) patients, the aspiration was not successful in collecting enough material for culture. The majority of these cases were at the beginning of the study, and the inability to collect specimens may be related to the early part of the learning curve for the aspiration procedure. The specificity of the positive results was 91%, as additional organisms were discovered from the culture results of the specimens collected during surgery in three patients. Only one of these three patients had recurrence of infection at 6 months postoperatively. Improving the accuracy and specificity of preoperative aspiration is an important task that may influence decision making and results in the future.

One of the observations that was made in the hips that received SS revision was that infected tissues were found only after incising the iliotibial tract, and in 29 cases infected tissues were found deep to the muscle envelop of the hip. Infected membranes were at the prosthesis bone interface and in the hip capsule. It was also noted that pus and infected membranes tracked through the gluteus medius muscle fibers to the superficial surface of the greater trochanter when the previous approach was an anterolateral approach. Pus and infected membranes were retrieved when the short external rotators and vastus lateralis muscles were reflected. In many cases acetabular and/or femoral bone erosion was noticed, but the infection remained within the muscle envelop.

This observation raised the idea of calling this type of infection as contained infection, as it remained confined to the hip space even though the actual hip space had extended to penetrate the floor of the acetabulum or the femoral cortices. Debridement of all infected tissues in this case will leave the hip within well-perfused soft tissue envelop without dead space. Adding the AB-loaded cancellous graft within that confined space would create a suitable environment for defending the new implant against colonization by bacteria or formation of biofilm.

In contrast, hips with draining sinuses and fibrotic muscles have infected tissues spreading through all soft tissue planes. The extent of the infection process cannot be predicted and the necessary aggressive debridement is likely to leave behind a dead space. Therefore, the nonconfined infection process was called as uncontained infection.

In this series, high doses of local AB (vancomycin and meropenem) ([Figure 1]) were added to the fresh frozen allograft. AB-impregnated cancellous graft was successfully used in previous studies [39],[40] and was found to deliver locally a very high concentration of the ABs that can affect not only the planktonic form of bacteria but also the sessile clusters and biofilm colonization [6].

The most commonly used AB for impregnation of cancellous graft is vancomycin [8],[39]. It was found to elute locally from bone graft and deliver very high concentrations that are several folds above the MIC of the sensitive bacteria, especially the methicillin-resistant Staphylococcus aureus [17]. However, in this series other gram-negative bacteria like Escherichia coli and Klebsiella spp. were identified in many cases preoperatively ([Table 1]). The combination of vancomycin and meropenem was found to have a synergistic effect and had been previously tested and delivered in conjunction with bone cement [22],[23],[41]. Therefore, the choice of AB added to cancellous bone graft was according to the preoperative identification of the infecting organism and its sensitivity profile. This is likely to improve the efficacy of the local AB and increase its ability on defending the new implant and inhibit colonizing the biofilm.

Various strategies have been employed to overcome bone defects in the setting of revision hip arthroplasty, including filling defects with bone cement, which is usually associated with early loosening, bulk or impaction graft [42], and finally the tantalum metal augments [43]. Although there is increasing interest in the use of Tantalum augments to provide structural support and enhance the implant stability [44], in itself the augments do not have a role in eradicating infection [43]. Cancellous impaction graft does not only provide a biologic fill for acetabular defects that would increase the bone stock but plays a role in cases of infection as a good carrier for the AB [8],[18].

Postoperative AB protocol was decided according to the type of the infecting organism. A minimum of 2 weeks on intravenous AB was given to all cases in the SS. Oral AB when organism sensitivity profile allowed was then given for 4–8 weeks. In 32/33 patients the CRP was less than 6 by the fourth week, which is in addition to reduction of the ESR curve in all cases.The limitations of this study are the small number of patients and the fact that patients were not randomized into groups as per treatment. However, it has tested a protocol for patients’ selection and has reported its outcome.

It was not possible to test the effect of using large doses of ABs to the BG on the other body systems. However, these AB are widely used in the treatment of periprosthetic infection and have been previously tested with bone cement both in vitro and in vivo with no reported adverse effects [39].

In this study, patients’ inclusion into the SS revision group was determined by the extent of the infection process and preoperative identification of the organism. The strict selection criteria for this group of patients resulted in a 97% success rate at an average of 4 years’ (range: 2–7 years) follow-up. Previous studies that employed the SS exchange strategy achieved variable rates of success from 54% [1] to 90% [6] but included patients with uncontained infection and without prior identification of the organism. When a standard protocol for patients’ selection was followed higher rates of success were achieved [3],[13].


The benefit of SS revision to the patients, the health system, and to the society is remarkable when compared with the TS exchange. The challenge has always been on achieving similar or higher rates of success in the eradication of infection when compared with the TS reimplantation protocol. Restricting the SS revision protocol to patients with contained periprosthetic infection with prior identification of the organism seems to achieve excellent results at mid-term follow-up. It remains to be seen whether this strategy will stand the test of time.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


1Leonard HA, Liddle AD, Burke O, Murray DW, Pandit H. Single- or two-stage revision for infected total hip arthroplasty? A systematic review of the literature. Clin Orthop Relat Res 2014; 472:1036–1042.
2Parvizi J, Zmistowski B, Adeli B. Periprosthetic joint infection: treatment options. Orthopedics 2010; 33:659–665.
3Gehrke T, Kendoff D. Peri-prosthetic hip infections: in favour of one-stage. Hip Int 2012; 8(Suppl):S40–S45.
4Hansen E, Tetreault M, Zmistowski B, Della Valle CJ, Parvizi J, Haddad FS et al. Outcome of one-stage cementless exchange for acute postoperative periprosthetic hip infection. Clin Orthop Relat Res 2013; 471:3214–3222.
5Munoz-Mahamud E, Gallart X, Soriano A. One-stage revision arthroplasty for infected hip replacements. Open Orthop J 2013; 7:184–189.
6Winkler H. Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft. Int J Med Sci 2009; 6:247–252.
7Bori G, Munoz-Mahamud E, Cune J, Gallart X, Fuster D, Soriano A. One-stage revision arthroplasty using cementless stem for infected hip arthroplasties. J Arthroplasty 2014; 29:1076–1081.
8Winkler H, Stoiber A, Kaudela K, Winter F, Menschik F. One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics. J Bone Joint Surg Br 2008; 90:1580–1584.
9Wolf M, Clar H, Friesenbichler J, Schwantzer G, Bernhardt G, Gruber G et al. Prosthetic joint infection following total hip replacement: results of one-stage versus two-stage exchange. Int Orthop 2014; 38:1363–1368.
10Ibrahim MS, Raja S, Khan MA, Haddad FS. A multidisciplinary team approach to two-stage revision for the infected hip replacement: a minimum five-year follow-up study. Bone Joint J 2014; 96:1312–1318.
11McKenna PB, O’Shea K, Masterson EL. Two-stage revision of infected hip arthroplasty using a shortened post-operative course of antibiotics. Arch Orthop Trauma Surg 2009; 129:489–494.
12Wolf CF, Gu NY, Doctor JN, Manner PA, Leopold SS. Comparison of one and two-stage revision of total hip arthroplasty complicated by infection: a Markov expected-utility decision analysis. J Bone Joint Surg Am 2011; 93:631–639.
13Oussedik SI, Dodd MB, Haddad FS. Outcomes of revision total hip replacement for infection after grading according to a standard protocol. J Bone Joint Surg Br 2010; 92:1222–1226.
14Parvizi J, Suh DH, Jafari SM, Mullan A, Purtill JJ. Aseptic loosening of total hip arthroplasty: infection always should be ruled out. Clin Orthop Relat Res 2011; 469:1401–1405.
15McPherson EJ, Woodson C, Holtom P, Roidis H, Shufelt C, Patzakis M. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res 2002; 8–15.
16Chen WM, McAuley JP, Engh CA Jr, Hopper RH Jr, Engh CA. Extended slide trochanteric osteotomy for revision total hip arthroplasty. J Bone Joint Surg Am 2000; 82:1215–1219.
17Buttaro M, Comba F, Piccaluga F. Vancomycin-supplemented cancellous bone allografts in hip revision surgery. Clin Orthop Relat Res 2007; 461:74–80.
18Witso E, Persen L, Loseth K, Benum P, Bergh K. Cancellous bone as an antibiotic carrier. Acta Orthop Scand 2000; 71:80–84.
19Witso E, Persen L, Loseth K, Bergh K. Adsorption and release of antibiotics from morselized cancellous bone. In vitro studies of 8 antibiotics. Acta Orthop Scand 1999; 70:298–304.
20Ibrahim MS, Raja S, Haddad FS. Acetabular impaction bone grafting in total hip replacement. Bone Joint J 2013; 95-B:98–102.
21Krbec M, Adler J, Messner P Jr. Bone grafts in hip prosthesis revisions. Acta Chir Orthop Traumatol Cech 2003; 70:83–88.
22Andollina A, Bertoni G, Zolezzi C, Trentani F, Trentani P, Maria Borrelli A et al. Vancomycin and meropenem in acrylic cement: elution kinetics of in vitro bactericidal action. Chir Organi Mov 2008; 91:153–158.
23Baleani M, Persson C, Zolezzi C, Andollina A, Borrelli AM, Tigani D. Biological and biomechanical effects of vancomycin and meropenem in acrylic bone cement. J Arthroplasty 2008; 23:1232–1238.
24Galvez-Lopez R, Pena-Monje A, Antelo-Lorenzo R, Guardia-Olmedo J, Moliz J, Hernandez-Quero J et al. Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement. Diagn Microbiol Infect Dis 2014; 78:70–74.
25Slooff TJ, Buma P, Schreurs BW, Schimmel JW, Huiskes R, Gardeniers J. Acetabular and femoral reconstruction with impacted graft and cement. Clin Orthop Relat Res 1996; 108–115.
26Slooff TJ, Schimmel JW, Buma P. Cemented fixation with bone grafts. Orthop Clin North Am 1993; 24:667–677.
27DeLee JG, Charnley J. Radiological demarcation of cemented sockets in total hip replacement. Clin Orthop Relat Res 1976; 20–32.
28Ghanem E, Parvizi J, Burnett RS, Sharkey PF, Keshavarzi N, Aggarwal A et al. Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint surg Am 2008; 90:1637–1643.
29Haddad FS, Bridgens A. Infection following hip replacement: solution options. Orthopedics 2008;31:907–908.
30Moyad TF, Thornhill T, Estok D. Evaluation and management of the infected total hip and knee. Orthopedics 2008; 31:581–588.
31Winkler T, Trampuz A, Hardt S, Janz V, Kleber C, Perka C. Periprosthetic infection after hip arthroplasty. Orthopade 2014; 43:70–78.
32Ali F, Wilkinson JM, Cooper JR, Kerry RM, Hamer AJ, Norman P et al. Accuracy of joint aspiration for the preoperative diagnosis of infection in total hip arthroplasty. J Arthroplasty 2006; 21:221–226.
33Battaglia M, Vannini F, Guaraldi F, Rossi G, Biondi F, Sudanese A. Validity of preoperative ultrasound-guided aspiration in the revision of hip prosthesis. Ultrasound Med Biol 2011; 37:1977–1983.
34Muller M, Morawietz L, Hasart O, Strube P, Perka C, Tohtz S. Diagnosis of periprosthetic infection following total hip arthroplasty − evaluation of the diagnostic values of pre- and intraoperative parameters and the associated strategy to preoperatively select patients with a high probability of joint infection. J Orthop Surg Res 2008; 3:31–39.
35Qu X, Zhai Z, Wu C, Jin F, Li H, Wang L et al. Preoperative aspiration culture for preoperative diagnosis of infection in total hip or knee arthroplasty. J Clin Microbiol 2013; 51:3830–3834.
36Chalmers PN, Sporer SM, Levine BR. Correlation of aspiration results with periprosthetic sepsis in revision total hip arthroplasty. J Arthroplasty 2014; 29:438–442.
37Williams JL, Norman P, Stockley I. The value of hip aspiration versus tissue biopsy in diagnosing infection before exchange hip arthroplasty surgery. J Arthroplasty 2004; 19:582–586.
38Phillips WC, Kattapuram SV. Efficacy of preoperative hip aspiration performed in the radiology department. Clin Orthop Relat Res 1983; 141–146.
39Buttaro MA, Gimenez MI, Greco G, Barcan L, Piccaluga F. High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties. Acta Orthop 2005; 76:336–340.
40Buttaro MA, Pusso R, Piccaluga F. Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty. Two-stage revision results. J Bone Joint Surg Br 2005; 87:314–319.
41Persson C, Baleani B, Guandalini L, Tigani D, Viceconti M. Mechanical effects of the use of vancomycin and meropenem in acrylic bone cement. Acta Orthop 2006; 77:617–621.
42Buttaro MA. Bone grafting and two-stage revision total hip arthroplasty. Hip Int 2012; 8(Suppl):S69–S74.
43Klatte TO, Kendoff D, Sabihi R, Kamath AF, Rueger JM, Gehrke T. Tantalum acetabular augments in one-stage exchange of infected total hip arthroplasty: a case-control study. J Arthroplasty 2014; 29:1443–1448.
44Davies JH, Laflamme GY, Delisle J, Fernandes J. Trabecular metal used for major bone loss in acetabular hip revision. J Arthroplasty 2011; 26:1245–1250.