|Year : 2019 | Volume
| Issue : 1 | Page : 45-51
Outcomes of two minimally invasive decompressive techniques for degenerative lumbar spinal stenosis
Mohamed Hussein, Amr Eladawy, Tarek A El-Hewala
Orthopedic Surgery Department, Faculty of Medicine, Zagazig University Hospitals, Zagazig City, Sharkiah, Egypt
|Date of Submission||02-Apr-2019|
|Date of Acceptance||28-Apr-2019|
|Date of Web Publication||24-Sep-2019|
MD Mohamed Hussein
Department of Orthopedics and Traumatology Surgery, Faculty of Medicine, New Hospital, 4th Floor, Zagazig University Hospitals, Zagazig University, Zagazig City, Sharkiah 44519
Source of Support: None, Conflict of Interest: None
Background Minimally invasive decompressive procedures have evolved into the modern standard surgical solution for degenerative lumbar spinal stenosis (DLSS) patients, such as the bilateral laminotomy and the unilateral laminotomy for bilateral decompression (ULBD) that is characterized by ipsilateral and contralateral microdecompression under the midline posterior structures and has been successfully used with proven efficacy.
Objective To compare the effect of the size of the skin incision and the method of handling the multifidus muscle on the clinical outcomes of the endoscopic laminotomy versus the standard microscopic laminotomy for DLSS.
Patients and methods Primary outcome data included the numerical rating scale for back and leg symptoms and Oswestry Disability Index to quantify pain and disability, respectively. Secondary outcome data included operative time, blood loss, and modified Mcnab criteria.
Results At the end of the follow-up period, the rate of successful outcome of the endoscopic group was 87.2 and 77.8% for the control group after initial improvement by 87% at 3-month follow-up. The incidence of complications was 13% in both groups.
Conclusion For DLSS, the endoscopic ULBD in experienced hands would have a better outcome than the microscopic ULBD regarding the postoperative clinical outcome and patient satisfaction.
Keywords: endoscopic, lumbar spinal stenosis, microscopic, spine
|How to cite this article:|
Hussein M, Eladawy A, El-Hewala TA. Outcomes of two minimally invasive decompressive techniques for degenerative lumbar spinal stenosis. Egypt Orthop J 2019;54:45-51
|How to cite this URL:|
Hussein M, Eladawy A, El-Hewala TA. Outcomes of two minimally invasive decompressive techniques for degenerative lumbar spinal stenosis. Egypt Orthop J [serial online] 2019 [cited 2020 Jul 14];54:45-51. Available from: http://www.eoj.eg.net/text.asp?2019/54/1/45/267732
| Introduction|| |
Degenerative lumbar spinal stenosis (DLSS) is the most common cause for spinal surgery in the geriatric population . Neurogenic claudication is the chief complaint of patients .
Open laminectomy has been traditionally the standard operative technique for DLSS with unsatisfactory long-term outcome ,. Aryanpur and Ducker  suggested that complete decompression may not be necessary to achieve symptomatic relief. Significant stenosis of up to 45% has been found in asymptomatic patients . Subsequently, minimally invasive decompressive procedures have evolved into the modern standard surgical solution for DLSS, such as the bilateral laminotomy , and the unilateral laminotomy for bilateral decompression (ULBD) which was initially described by Young et al.  and subsequently modified by McCulloch . This microscopic technique that is characterized by ipsilateral and contralateral microdecompression is performed under the midline posterior structures and has been successfully used with proven efficacy for the treatment of DLSS patients ,.
Successive tube dilators and retractors were designed to minimize disruption of the paraspinal musculature in endoscopic ULBD ,. Several studies have shown better patient outcomes of endoscopic ULBD when compared with those of the traditional open laminectomy ,,,.
A review of the literature has shown no studies comparing the clinical outcome of endoscopic versus microscopic ULBD. The goal of this study was to compare the effect of the size of the skin incision and the method of handling the multifidus muscle on the clinical outcomes of those two minimally invasive decompressive procedures for DLSS.
| Patients and methods|| |
This was a prospective, randomized, controlled trial of patients with DLSS. All the participants gave their written consent in accordance with the Helsinki Declaration . All the participants gave their written consent in accordance to the Helsinki Declaration. The study was approved by the Ethical Research Committees of Zagazig University Hospitals. We enrolled in our study 60 patients with clinically symptomatic DLSS who fulfilled the inclusion criteria for our study. The patients were divided into two groups: 30 patients each who were treated with either endoscopic ULBD (group A) utilizing the METRx system (Medtronic Sofamor Danek Inc., Memphis, Tennessee, USA), or microscopic ULBD (group B=control group) utilizing an operative microscope, at our Orthopaedic Department, Zagazig University, Egypt, between May 2012 and August 2016 and the last follow-up visit took place in August 2018.
Determination of the general indication for surgery was made by the authors who experienced spine surgeons, randomization was open since the patients must sign a detailed informed consent and was made by the nonphysician study staff alternating between the endoscopic ULBD and the microscopic ULBD in the sequence of presentation were allocated so that patient 1 got the first type of surgery (Microendoscopic), and number 2 the second type (Microscopic). Preoperative MRI studies, and the T2-weighted axial MRI were reviewed to determine the level of stenosis. Preoperative lumbar dynamic (flexion–extension) radiographs were reviewed for evidence of instability. Furthermore, only patients who completed the 24 months of follow-up were included in the final analysis of this study. All operations were performed by the authors who have considerable experience in both techniques.
Inclusion criteria included (a) neurogenic claudications as expressed by the patients as leg pain and/or heaviness limiting standing, walking, or both; (b) a history of walking intolerance; (c) MRI confirmation of central canal stenosis (central sagittal diameter <10 mm) with or without lateral recess stenosis (lateral recess diameter <3 mm); and (d) failure of conservative therapy.
Exclusion criteria included (a) previous spinal surgery at the same level; (b) dynamic instability determined by the presence of sagittal vertebral translation greater than 3 mm and angulation more than 10° on a dynamic radiograph; (c) isthmic spondylolisthesis; (d) cauda equina syndrome; (e) far-lateral disk herniation pressing the nerve root in the extraforaminal region.
In group A, 14 men and 12 women ranged in age from 48 to 65 years (average, 56.5 years). In group B, 16 men and 11 women ranged in age from 49 to 67 years (average, 58 years). Thirty-eight (71.7%) patients were 60 years of age or older. The mean duration of symptoms was 12.6 months for group A and 13.5 months for group B. All patients had received conservative treatment in the form of limited daily activity, NSAIDs, muscle relaxants, neurotrophins, opioid analgesics, and a comprehensive course of 30 sessions of physiotherapy (mean, 5.2 months). Patient characteristics are listed in [Table 1]. Patients of both groups had a very similar clinical profile (e.g. radicular pain related to exercise and radiculopathic neurological deficits such as numbness, muscle weakness, and/or hyporeflexia). Overall, a total of 72 laminotomies were performed in the 53 patients; 36 (68%) patients (group A, 19 and group B, 17) were decompressed at one level, 15 (28.3%) patients (group A, seven and group B, eight) at two levels, and two (3.8%) patients (one patient for each group) at three levels.
Primary (subjective) outcome data included: numerical rating scale (NRS) (range, 0–100)  for back and leg symptoms and Oswestry disability index (ODI) , version 2.0. The final score is calculated and presented as a percentage (0% represents no pain and disability and 100% represents the worst possible pain and disability) both NRS and ODI were used for preoperative and postoperative evaluation. The modified Mcnab criteria  were used only for postoperative evaluation.
Secondary (objective) outcome data included: (a) all the patients who had preoperative lumbar dynamic (flexion–extension) radiographs and 3, 12, and 24 months postoperative lumbar dynamic (flexion–extension) radiographs. These were reviewed for evidence of instability and/or progression of spondylolisthesis. A single radiologist who was not affiliated with the study, blinded to the procedure and the clinical results of decompression, reviewed all preoperative and postoperative studies. (b) Operative time and blood loss ([Table 1]). Reoperation at the same level for any reason was considered a poor outcome, regardless of the ultimate level of function.
Endoscopic unilateral laminotomy for bilateral decompression
After introduction of general anesthesia, the stenotic level was localized by fluoroscopy. After making an 18–25 mm paramedian skin incision, a rigid endoscope was inserted into the tubular retractor. Unilateral laminotomy and flavectomy were performed endoscopically ([Figure 1]).
|Figure 1 Endoscopic views: (a) nerve root retractor retracting the dural sac and nerve root medially to undermine the lateral recess or to perform discectomy and (b) the dural sac after decompression.|
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A careful medial facetectomy was performed enough to decompress the lateral recess and undermine the entrance zone of the foramen to decompress the exiting nerve root. A long 90° ball-tipped probe was passed through the foramen over the nerve root to insure that there is no residual foraminal stenosis. At this stage, a discectomy could be performed if the bulging dis is one of the stenosing elements ([Figure 2]). The endoscope was then angulated medially to visualize the volar surface of the spinous process which was undercut by a burr or a Kerrison punch ([Figure 2]). The hypertrophied medial facet was partially resected after contralateral laminotomy and flavectomy. The whole procedure was repeated at the contralateral side of the neighboring stenotic level only, when there is a long-segment (two or more levels) stenosis as planed preoperatively. The reason of bilateral approach on different levels is to avoid formation of one long continuous incision made by two or more neighboring small incisions (endoscopic or microscopic) in long-segment lumbar stenosis. The incision was closed in layers by using Vicryl.
|Figure 2 Endoscopic ULBD (left), using the pituitary rongeur and suction during the discectomy step of the decompression procedure. Note the angle of the tubular retractor to decompress midline and contralateral structures. ULBD, unilateral laminotomy for bilateral decompression.|
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Microscopic unilateral laminotomy for bilateral decompression
After patient preparation, a 3–6 cm (according to the patient’s body build) midline skin incision was made and the paraspinal muscles were retracted using a self-retaining retractor. The operative microscope was brought and adjusted over the incision after being covered by sterilized draping. Then the surgical procedure was done exactly as in the endoscopic procedure for the ipsilateral side and the contralateral side after medial angulation of the operative microscope ([Figure 3]).
|Figure 3 Open microscopic ULBD (left), using the self-retaining retractor to laterally retract the lumbar multifidus muscle and open microscopic ULBD (right), using the probe during flavectomy. The microscope is covered with sterilized draping. ULBD, unilateral laminotomy for bilateral decompression.|
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The mean period of follow-up in group A was 24.55±1.57 months and 24.29±1.74 months in group B. The patients were followed up at 3, 12, and 24 months. Follow-up data were obtained from clinic follow-up visits by two independent physicians: before surgery, after surgery at day 1 (60 patients in hospital before discharge). All patients had intramuscular NSAID injection for pain control and mobilization was permitted after complete recovery from anesthesia but strenuous activities were postponed until 1–2 moths postoperatively, 2 weeks for stitches removal, 3 months (58 patients), 12 months (56 patients), and at the final follow-up visit at 24 months (53 patients) (88.3%). The final follow-up visit took place in August 2017.
We analyzed only the results of the patients who completed at least 24 months of follow-up. Seven patients were lost for the following reasons: two surgery-unrelated deaths and five patients did not attend the outpatient clinic follow-up visits. The final count was 53 (88.3%) patients in both groups. Four patients 26/30(86.7%) were lost in group A, and three 27/30 (90%) patients were lost in group B.
All statistical analyses were carried out using the SPSS (Statistical Package of Social Sciences; SPSS Inc., Chicago, Illinois, USA) for Windows software program, version 17.0. A P value of less than 0.05 was considered statistically significant. The results were expressed as mean±SD. Paired t test and a χ2 test were used to test the differences between the two groups in terms of categorical data and one-way analysis of variance test was used to test for significant differences between baseline and for various follow-up measurements.
| Results|| |
In the endoscopic group, the mean operative time was 90.18±10.36 min. The mean blood loss was 36.11±9.19 ml. In the control group, the mean operative time was 93.14±10.78 min. The mean blood loss was 52.77±9.6 ml ([Table 1]).
In the endoscopic group, the neurogenic claudicant leg pain relief was statistically significant, the mean NRS leg score significantly decreased from 7.61±0.91 to 1.21±0.59 (P=0.001) postoperatively, whereas the mean back pain insignificantly increased from 3.2±0.89 to 3.6±0.54 postoperatively (P=0.584) and remained stable till the final follow-up evaluation. In the control group, the leg pain relief was statistically significant, the mean NRS leg score significantly decreased from 7.5±0.9 preoperatively to 1.27±0.71 (P=0.001). The score was taken during the first week postoperatively and remained stable till the final follow-up evaluation, whereas the mean NRS back pain insignificantly increased from 3.11±0.76 preoperatively to 3.8±0.4 postoperatively(P=0.523) during the first 12 months postoperatively, then it significantly increased to 6.8±0.4 at the final follow-up evaluation (P=0.001). There was no statistically significant difference between the mean NRS back pain and leg pain preoperative scores of the two groups (P=0.262) (P=0.308) ([Table 2]).
In the endoscopic group, the disability improvement was statistically significant and the mean ODI score significantly decreased from 73.036±5.64% preoperatively to 16.69±6% at the final follow-up. In the control group, the disability improvement was statistically significant and the mean ODI score significantly decreased from 72.37±5.94% preoperatively to 22.25±7.2% at the final follow-up (P=0.001). There was no statistically significant difference between the mean preoperative scores of the two groups (P=0.326) ([Table 2]).
At the final evaluation, according to Mcnab criteria, in the endoscopic group, the overall results were good to excellent in 84.6% (22/26) of the patients, fair in 11.5% (3/26), and poor in 3.8% (1/26). In the control group, at the final evaluation, according to Mcnab criteria, the overall results were good to excellent in 77.8% (21/27) of the patients, fair in 7.4% (2/27), and poor in 14.8% (4/27) ([Table 3]).
If the excellent and good categories were regarded as successful and fair and poor were considered failures, the total success rate of the endoscopic group was 84.6%. For the control group, the success rate was77.8% at the end of the follow-up period.
There were no serious complications in either group, such as nerve root injury, cauda equina syndrome, spondylodiscitis, or deep venous thrombosis. Dural tears were encountered in two (7.7%) patients in the endoscopic group A and three (11.1%) patients in the microscopic group B. Fortunately, the five dural tears were tiny and were managed using SurgiSeal and tailored patch form dorsolumbar fascia without residual postoperative cerebrospinal fluid leakage. One (3.7%) patient in the microscopic group and one (3.8%) patient in the endoscopic group had superficial wound infection.
During the follow-up period, five (9.4%) patients underwent reoperation; two patients underwent repeated decompression at previously operated levels due to residual stenosis or restenosis (one patient in each group); and three patients underwent spinal fusion for progressive lumbar instability due to decompression of two or three motion segments [one (3.8%) patient in the endoscopic group A and two (7.4%) patients in the microscopic group B]. These patients were partially recovered after the repeated surgery, but remained in the poor outcome group during the long-term follow-up.
| Discussion|| |
Getty et al.  introduced unilateral and bilateral laminotomy for decompression of DLSS as a less invasive surgical option. Comparable results have been reported since then and the success rate ranged from 59 to85.3% ,.
In the present study, the surgical complication rate in the endoscopic group was 3.6% (two patients had accidental durotomy) and in the microscopic group was 9.3% (two patients had accidental durotomy and three patients had wound infection) which is comparable to those reported by other studies ,,,,,,,,. Also, the 8.3% incidence of reoperation for restenosis and secondary spinal instability is comparable to those reported by other studies in the literature ,,.
The overall results of both groups were comparable during the first 12 months of the postoperative period. Although the mean ODI and NRS leg and back scores for the endoscopic group and the mean ODI and NRS leg scores for the control group showed significant improvement at the end of the 36 months follow-up period, the NRS back scores for the control group showed deterioration at 36 months after initial significant improvement at 3–12 months follow-up postoperatively (P<0.001) ([Table 2]). This may be explained by the technical differences between the two procedures such as the size of skin incision and the method of handling of the lumbar multifidus (LMF) muscles. In the endoscopic technique we used a muscle-splitting approach using sequential dilators and a 20 mm diameter tubular retractor, whereas in the microscopic technique we made a 3–6 cm skin incision according to the patient’s body build, and an LMF muscle stripping and retraction approach to gain access to the spinal canal with the high possibility of injury to the medial branch of the dorsal ramus ([Figure 4]).That nerve courses around the superior articular process lies in a groove between the mammillary process and the accessory process and supplies the LMF muscle and its inevitable tethering by retraction of the LMF muscle will lead to LMF muscle denervation and subsequent decrease in its strength with associated atrophy on postoperative computed tomography  and electromyographic studies that was correlated with postoperative failed-back surgery syndrome .
|Figure 4 (a) Postoperative MRI axial view showing the endoscopic right laminotomy boundaries with intact but undermined left lamina, also showing the near-normal appearance of the lumbar multifidus muscle with minimal degree of fibrosis on the endoscopic right laminotomy side. (b) MRI axial view (1-year postmicroscopic ULBD) shows the decompressed lumbar spinal canal and lateral recess with preserved facet joints (yellow circle), it also shows the increased amount of fibrosis in the lumbar multifidus muscle on the operated side (right side). ULBD, unilateral laminotomy for bilateral decompression.|
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The current study presents the first comparison study between two minimally invasive techniques for the treatment of DLSS. The 36 months follow-up period allowed observation of the persistence of the initial good outcome. Also, the prospective nature, the homogeneity of the patient population, the detailed prescription of the surgical procedures, and the independent observers are strengths of the current study.
One of the shortcomings of our study is the relatively small number of patients in both groups. Another shortcoming is that postoperative spinal computed tomography or MRI scans to assess the amount of decompression were not performed routinely. However, the amount of radiologically confirmed decompression is poorly correlated to the surgical outcome ,. Niggemeyer et al.  found in their meta-analysis that the least invasive surgical procedure and decompression without any fusion could obtain the most favorable results in patients with DLSS.
| Conclusion|| |
For DLSS, the endoscopic ULBD in experienced hands would have a better outcome than the microscopic ULBD regarding the postoperative clinical outcome and patient satisfaction and we recommend the use of a tubular retractor system that allows gradual muscle splitting, preserve spinal stability, and that can be used efficiently with an endoscope or a microscope and their use remains a subject of the surgeon’s preference.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Fu Y-S, Zeng B-Z, Xu J-G. Long-term outcomes of two different decompressive techniques for lumbar spinal stenosis. Spine 2008; 33:514–518.
Kalichman L, Cole R, Kim DH, Li L, Suri P, Guermazi A et al.
Spinal stenosis prevalence and association with symptoms: the Framingham study. Spine 2009; 9:545–550.
Verbiest H. Results of surgical treatment of idiopathic developmental stenosis of the lumbar vertebral canal. A review of twenty-seven years’ experience. JBJS Br 1977; 59:181–188.
Katz JN, Lipson SJ, Chang LC, Levine SA, Fossel AH, Liang MH. Seven- to ten-year outcome of decompressive surgery for degenerative lumbar spinal stenosis. Spine 1996; 21:92–98.
Aryanpur J, Ducker T. Multilevel lumbar laminotomies: an alternative to laminectomy in the treatment of lumbar stenosis. Neurosurgery 1990; 26:429–433.
Hitselburger WE, Witten RM. Abnormal myelograms in asymptomatic patients. J Neurosurg 1968; 28:204–206.
Thomas NW, Rea GL, Pikul BK, Mervis LJ, Irsik R, McGregor JM. Quantitative outcome and radiographic comparisons between laminectomy and laminotomy in the treatment of acquired lumbar stenosis. Neurosurgery 1997; 41:567–575.
Young S, Veerapen R, O’Laoire SA. Relief of lumbar canal stenosis using multilevel subarticular fenestrations as an alternative to wide laminectomy: preliminary report. Neurosurgery 1988; 23:628–633.
McCulloch JA. Microsurgery for lumbar spinal stenosis. In: McCulloch JA, Young PH, eds. Essentials of spinal microsurgery. Philadelphia: Lippincott-Raven 1998:453–486
Cavusoglu H, Türkmenoglu O, Kaya RA, Tuncer C, Colak I, Sahin Y et al.
Efficacy of unilateral laminectomy for bilateral decompression in lumbar spinal stenosis. Turk Neurosurg 2007; 17:100–108.
Orpen NM, Corner JA, Shetty RR, Marshall R. Micro-decompression for lumbar spinal stenosis: The early outcome using a modified surgical technique. JBJS (Br) 2010; 92-B:550–554.
Roh SW, Kim DH, Cardoso AC, Fessler RG. Endoscopic foraminotomy using MED system in cadaveric specimens. Spine 2000; 25:260–264.
Guiot BH, Khoo LT, Fessler RG. A minimally invasive technique for decompression of the lumbar spine. Spine 2002; 27:432–438.
Palmer S, Turner R, Palmer R. Bilateral decompressive surgery in lumbar spinal stenosis associated with spondylolisthesis: unilateral approach and use of a microscope and tubular retractor system. Neurosurg Focus 2002; 13:E4.
Asgarzadie F, Khoo LT. Minimally invasive operative management for lumbar spinal stenosis: overview of early and long-term outcomes. Orthop Clin North Am 2007; 38:387–399.
Rosen DS, O’Toole JE, Eichholz KM, Hrubes M, Huo D, Sandhu FA, Fessler RG. Minimally invasive lumbar spinal decompression in the elderly: outcomes of 50 patients aged 75 years and older. Neurosurgery 2007; 60:503–509.
O’Toole JE, Eichholz KM, Fessler RG. Surgical site infection rates after minimally invasive spinal surgery: clinical article. J Neurosurg 2009; 11:471–476.
Derby R, Howard MW, Grant GM, Lettice JJ, Van Peteghem PK, Ryan DP. The ability of pressure controlled discography to predict surgical and nonsurgical outcomes. Spine 1999; 24:364–372.
Fairbank J, Pynsent P. The Oswestry Disability Index. Spine 2000; 25:2940–2953.
MacNab I. Negative disc exploration. JBJS (Am) 1971; 53:891–903.
Getty CJM, Johnson JR, Kirwan EO, Sullivan MF. Partial undercutting facetectomy for bony entrapment of the lumbar nerve root. J Bone Joint Surg Br 1981; 63:330–335.
Mayer T, Gatchel R, Betancur J, Bovasso E. Trunk muscle endurance measurement. Isometric contrasted to isokinetic testing in normal subjects. Spine 1995; 20:920–926.
Sihvonen T, Herno A, Paljarva L, Airaksinen O, Patanen J, Tapaninaho A. Local denervation atrophy of paraspinal muscles in postoperative failed back syndrome. Spine 1993; 18:575–581.
Fox MW, Onofrio BM, Hanssen AD. Clinical outcomes and radiological instability following decompressive lumbar laminectomy for degenerative spinal stenosis: a comparison of patients undergoing concomitant arthrodesis versus decompression alone. J Neurosurg 1996; 85:793–802.
Herno A, Airaksinen O, Saari T, Pitkänen M, Manninen H, Suomalainen O. Computed tomography findings 4 years after surgical management of lumbar spinal stenosis: no correlation with clinical outcome. Spine 1999; 24:2234–2239.
Niggemeyer O, Strauss JM, Schulitz KP. Comparison of surgical procedures for degenerative lumbar spinal stenosis: a meta-analysis of the literature from 1975to1995. Eur Spine J 1997; 6:423–429.
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2], [Table 3]